Gonzalez, Claudette Hajaj; Marques-Dias, Maria Joaquina; Kim, Chong Ae; Sugayama, Sofia MM.; Da Paz, José Albino; Huson, Susan M.; Holmes, Lewis B.

Congenital abnormalities in Brazilian children associated with misoprostol misuse in first trimester of pregnancy
Gonzalez, Claudette Hajaj; Marques-Dias, Maria Joaquina; Kim, Chong Ae; Sugayama, Sofia MM.; Da Paz, José Albino; Huson, Susan M.; Holmes, Lewis B. - 1998 - Lancet, 351, 9116, 1624-7

Palabras claves : aborto inducido; agentes abortivos; anormalidades congénitas; anticoncepción de emergencia; biología; educación en planificación familiar; efectos secundarios; embarazo; enfermedades; enfermedades congénitas; enfermedades y malformaciones congénitas; estudio de caso; estudios; estudios de caso; feto; fisiología; fracasos de aborto; medicamentos abortivos; metodología; métodos; métodos abortivos; misoprostol; planificación familiar; prostaglandinas; reproducción
País : America del Sur; America Del Sur; América latina; Brasil; Latina America; País en desarrollo; Sudamérica

Resumen : In Brazil and other South and Central American countries where abortion is illegal, misoprostol is widely available and commonly used to induce abortion. However, misoprostol is not very effective as an abortifacient agent and can cause fetal abnormalities. The present study reviewed the cases of 42 infants from Sao Paulo, Brazil, who were exposed to misoprostol during the first trimester of pregnancy and then born with a congenital abnormality. 17 children had equinovarus with cranial nerve deficiencies and 10 had equinovarus as part of a more extensive arthrogryposis. The most distinctive phenotypes were arthrogryposis confined to the legs (5 cases) and terminal transverse limb defects (9 cases). Congenital hydrocephalus was present in 8 children. The most commonly taken dose of misoprostol was 800 mcg (range, 200-16,000 mcg). Greater awareness of the widespread use of misoprostol to induce abortion should lead to public health interventions to prevent teratogenic effects.

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Notes : Inglés/anglais/English, nbsp;Abstract : Popline (http://db.jhuccp.org/popinform/basic.html) - PIP 134505